The Toxic Dose of Nicotine: Shattering the Myth. The first port of call in any discussion such as this is to address a long-standing myth. Even today, many high-profile sources list the toxic dose of nicotine (the LD50 – or the dose that will kill about half of men and women exposed) as between 30 and 60 mg.
To put this in context of Vapor Cigarette, this would be about 4 ml of 12 mg/ml e-liquid. Your body does process nicotine quite quickly (your blood nicotine levels will decrease by about half after a couple of hours), so you’d have to consume everything basically all at once, which makes it still a significant tall order.
However, research by Bernd Mayer indicates this value for your toxic dose is completely indefensible. Inside the paper, he details several cases by which people consumed much larger quantities of nicotine with only minimal symptoms. On the top of this, the lowest quantity of nicotine located in the blood of people who died from nicotine was about 20 times greater than existing guidelines. Mayer revises the LD50 of nicotine to an estimated 500 to 1000 mg (or .5 to 1 g) on the basis of those results.
The other real question is where did the “30 to 60 mg of nicotine will kill you” claim originate from? Mayer followed “circular and quite often misleading references” for a while and in the end hit on the source: a 1906 textbook from a German toxicologist.
About this basis alone, it’s clear that there are probably some difficulties with trusting this as being a source. He was actually a respected toxicologist at that time, but medical knowledge has advanced massively in the century since it was published, therefore it isn’t surprising that repeating this claim verbatim without any further analysis isn’t the most effective idea.
The textbook cited some self-experiments performed in the nineteenth century, in which experimenters had the equivalent of some cigarettes’ amount of nicotine and reported seizures and loss of consciousness. It goes without stating that there was clearly probably some error in measuring the dose: otherwise chain-smokers would regularly lose consciousness and possess seizures.
Signs You’ve Had Excessive Nicotine. Vapers aren’t likely to suffer nicotine poisoning, only one thing that’s not unusual has a tad too much nicotine in just one sitting. The greatest tell-tale sign you’ve reached this aspect is feeling nauseous. You might notice this right at the end of any long vaping session, and it’s effectively your body suggesting to have a break from vaping for a while.
Inside my experience, this nausea increases gradually, but it’s better to just take a rest whenever you notice it starting. This way it never becomes too unpleasant, and you won’t experience the most crucial other initial symptom: vomiting. This isn’t tough to avoid at all, and many vapers will have a rest on the first indication of nausea even without being advised to do so. You can also get yourself a headache if you’ve overdone it a bit, but nausea will be the easiest thing to take into consideration.
It’s unlikely you’ll actually be able to this stage by vaping, but it’s worth knowing the main things to watch out for. The most serious nicotine poisoning symptoms are even less likely to occur when you’re vaping, but they are worth mentioning anyway. Such as coma and seizures (like our 1800s experimenters experienced), slowed heartrate as well as in the worst cases, respiratory failure. It may not be as poisonous as much sources claim, nevertheless it is really still poisonous.
Are You Able To Get Nicotine Poisoning by Vaping? For vapers, the most important real question is whether this is certainly something to concern yourself with in reality. Could you vape your path to a nicotine overdose? Could you wind up with the more serious signs and symptoms of nicotine poisoning?
The easiest method to take into consideration this (and to acquire a straightforward answer!) is to determine how much e-juice you’d actually have to vaporize in the space of a couple of hours to hit the minimum toxic dose of around 500 mg.
Employing a 12 mg/ml e-juice, you’d must vaporize over 40 ml to approach 500 mg of nicotine vaporised. Realistically, this just isn’t going to take place. For an 18 mg/ml e-liquid, you’d still need to vape almost 28 ml of e-juice in a couple of hours to even have a chance.
This is really only step one, though, and the nicotine will have to enter into the vapour and be absorbed from your body before it may poison you.
Estimating this aspect is a bit tough, but research from Dr. Farsalinos looked at experienced vapers’ plasma nicotine levels after utilizing a mod as well as an 18 mg/ml e-liquid. The analysis didn’t make use of a modern device, but to respond to the true secret question here it’s a lot more than sufficient. The participants vaped 10 puffs in 5 minutes, then had one hour to djurpj the product however much they liked.
After a few minutes, experienced vapers wound up with about 8 nanograms (billionths of the gram) of nicotine per ml of blood. Right after the full 65 minutes, vapers plasma nicotine levels rose to 24.1 ng/ml, even though the highest recorded concentration was 48.1 ng/ml.
In Bernd Mayer’s paper, he points out that the minimum plasma concentration recorded from someone who died from nicotine overdose was 4,000 ng/ml (equal to 4 mg per liter).
Based on the vaper who got the highest plasma nicotine levels, her or his blood nicotine level will have to be over 80 times higher to achieve the minimum lethal dose. To pile on yet more implausibility, they’d have to achieve this in under 2 hours. Put simply, they’d have to get about 80 times more nicotine in their blood in less than twice the amount of time.
This will clearly show that vapers really can’t overdose on nicotine by using their e-cigarettes as intended. It seems unlikely that it’d be also physically possible to inhale just as much vapour as you’d need to.